STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report.
Identifieur interne : 000136 ( Main/Exploration ); précédent : 000135; suivant : 000137STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report.
Auteurs : Karl-Josef Gundermann [Pologne] ; Jürgen Müller [Allemagne] ; Karin Kraft [Allemagne]Source :
- Evidence-based complementary and alternative medicine : eCAM [ 1741-427X ] ; 2020.
Abstract
Aim
To review the published and unpublished experimental and clinical studies about the efficacy and tolerability of STW1 and to compare the results to the efficacy and tolerability of investigated NSAIDs in parallel.
Conclusion
STW1 is a reasonable alternative to NSAIDs with comparable efficacy and a superior safety profile. It is also suitable to reduce the intake of NSAIDs.
DOI: 10.1155/2020/7841748
PubMed: 32733586
PubMed Central: PMC7376409
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report.</title><author><name sortKey="Gundermann, Karl Josef" sort="Gundermann, Karl Josef" uniqKey="Gundermann K" first="Karl-Josef" last="Gundermann">Karl-Josef Gundermann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin 70-111, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin 70-111</wicri:regionArea><wicri:noRegion>Szczecin 70-111</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Jurgen" sort="Muller, Jurgen" uniqKey="Muller J" first="Jürgen" last="Müller">Jürgen Müller</name><affiliation wicri:level="3"><nlm:affiliation>I&D Phytomedicines, Steigerwald Arzneimittelwerk GmbH, Darmstadt 64295, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>I&D Phytomedicines, Steigerwald Arzneimittelwerk GmbH, Darmstadt 64295</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Kraft, Karin" sort="Kraft, Karin" uniqKey="Kraft K" first="Karin" last="Kraft">Karin Kraft</name><affiliation wicri:level="1"><nlm:affiliation>Chair of Naturopathic Medicine, University Medicine Rostock, Rostock 18057, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair of Naturopathic Medicine, University Medicine Rostock, Rostock 18057</wicri:regionArea><wicri:noRegion>18057</wicri:noRegion><wicri:noRegion>18057</wicri:noRegion><wicri:noRegion>Rostock 18057</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32733586</idno><idno type="pmid">32733586</idno><idno type="doi">10.1155/2020/7841748</idno><idno type="pmc">PMC7376409</idno><idno type="wicri:Area/Main/Corpus">000162</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000162</idno><idno type="wicri:Area/Main/Curation">000162</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000162</idno><idno type="wicri:Area/Main/Exploration">000162</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report.</title><author><name sortKey="Gundermann, Karl Josef" sort="Gundermann, Karl Josef" uniqKey="Gundermann K" first="Karl-Josef" last="Gundermann">Karl-Josef Gundermann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin 70-111, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin 70-111</wicri:regionArea><wicri:noRegion>Szczecin 70-111</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Jurgen" sort="Muller, Jurgen" uniqKey="Muller J" first="Jürgen" last="Müller">Jürgen Müller</name><affiliation wicri:level="3"><nlm:affiliation>I&D Phytomedicines, Steigerwald Arzneimittelwerk GmbH, Darmstadt 64295, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>I&D Phytomedicines, Steigerwald Arzneimittelwerk GmbH, Darmstadt 64295</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Kraft, Karin" sort="Kraft, Karin" uniqKey="Kraft K" first="Karin" last="Kraft">Karin Kraft</name><affiliation wicri:level="1"><nlm:affiliation>Chair of Naturopathic Medicine, University Medicine Rostock, Rostock 18057, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair of Naturopathic Medicine, University Medicine Rostock, Rostock 18057</wicri:regionArea><wicri:noRegion>18057</wicri:noRegion><wicri:noRegion>18057</wicri:noRegion><wicri:noRegion>Rostock 18057</wicri:noRegion></affiliation></author></analytic><series><title level="j">Evidence-based complementary and alternative medicine : eCAM</title><idno type="ISSN">1741-427X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Aim</b></p><p>To review the published and unpublished experimental and clinical studies about the efficacy and tolerability of STW1 and to compare the results to the efficacy and tolerability of investigated NSAIDs in parallel. </p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>STW1 is a reasonable alternative to NSAIDs with comparable efficacy and a superior safety profile. It is also suitable to reduce the intake of NSAIDs.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32733586</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1741-427X</ISSN><JournalIssue CitedMedium="Print"><Volume>2020</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Evidence-based complementary and alternative medicine : eCAM</Title><ISOAbbreviation>Evid Based Complement Alternat Med</ISOAbbreviation></Journal><ArticleTitle>STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report.</ArticleTitle><Pagination><MedlinePgn>7841748</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2020/7841748</ELocationID><Abstract><AbstractText Label="Aim" NlmCategory="UNASSIGNED">To review the published and unpublished experimental and clinical studies about the efficacy and tolerability of STW1 and to compare the results to the efficacy and tolerability of investigated NSAIDs in parallel. <i>Content.</i> STW1 (Phytodolor®) contains a fixed combination of extracts from aspen leaves and bark (<i>Populus tremula</i>), common ash bark (<i>Fraxinus excelsior</i>), and goldenrod herb (<i>Solidago virgaurea</i>). It belongs to the group of anti-inflammatory and antirheumatic drugs, and it is authorized for the treatment of painful disorders of degenerative and inflammatory rheumatic diseases. The individual components have complementary effects. Its multifocal mode of action includes antiphlogistic, analgesic, antiexudative, antioxidative, antipyretic, and antiproliferative properties. The effects of both STW1 and its components have been verified in comprehensive pharmacological investigations. Open and randomized, placebo- and verum-controlled, and single-blind (sb) or double-blind (db) clinical trials, performed in different subtypes of rheumatic diseases confirm the pharmacological evidence. Its efficacy is comparable to a range of standard nonsteroidal anti-inflammatory drugs (NSAIDs) studied in parallel, but it has a superior safety profile.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">STW1 is a reasonable alternative to NSAIDs with comparable efficacy and a superior safety profile. It is also suitable to reduce the intake of NSAIDs.</AbstractText><CopyrightInformation>Copyright © 2020 Karl-Josef Gundermann et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gundermann</LastName><ForeName>Karl-Josef</ForeName><Initials>KJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1204-1817</Identifier><AffiliationInfo><Affiliation>Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin 70-111, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Jürgen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>I&D Phytomedicines, Steigerwald Arzneimittelwerk GmbH, Darmstadt 64295, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kraft</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Chair of Naturopathic Medicine, University Medicine Rostock, Rostock 18057, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Evid Based Complement Alternat Med</MedlineTA><NlmUniqueID>101215021</NlmUniqueID><ISSNLinking>1741-427X</ISSNLinking></MedlineJournalInfo><CoiStatement>Prof. K.-J. Gundermann is an independent consultant for the company Steigerwald AG, Darmstadt, Germany; Dr. J. Müller is an employee of the company. Steigerwald AG provided all the available research reports (RR) and partly funded the review. Prof. K. Kraft has the chair of naturopathic medicine at the University Medicine of Rostock and received an honorary for scientific advice.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32733586</ArticleId><ArticleId IdType="doi">10.1155/2020/7841748</ArticleId><ArticleId IdType="pmc">PMC7376409</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Gen Hosp Psychiatry. 2009 May-Jun;31(3):206-19</Citation><ArticleIdList><ArticleId IdType="pubmed">19410099</ArticleId></ArticleIdList></Reference><Reference><Citation>Arzneimittelforschung. 1995 Feb;45(2):172-3</Citation><ArticleIdList><ArticleId IdType="pubmed">7710442</ArticleId></ArticleIdList></Reference><Reference><Citation>Arzneimittelforschung. 2000 Apr;50(4):362-72</Citation><ArticleIdList><ArticleId IdType="pubmed">10800635</ArticleId></ArticleIdList></Reference><Reference><Citation>Cochrane Database Syst Rev. 2011 Feb 16;(2):CD002948</Citation><ArticleIdList><ArticleId IdType="pubmed">21328257</ArticleId></ArticleIdList></Reference><Reference><Citation>Arzneimittelforschung. 1996 Aug;46(8):809-14</Citation><ArticleIdList><ArticleId IdType="pubmed">9125284</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Rheumatol. 2013 Jul-Aug;31(4 Suppl 78):S22-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24129132</ArticleId></ArticleIdList></Reference><Reference><Citation>Rheum Dis Clin North Am. 2000 Feb;26(1):13-27, vii</Citation><ArticleIdList><ArticleId IdType="pubmed">10680191</ArticleId></ArticleIdList></Reference><Reference><Citation>Rheumatology (Oxford). 2001 Jul;40(7):779-93</Citation><ArticleIdList><ArticleId IdType="pubmed">11477283</ArticleId></ArticleIdList></Reference><Reference><Citation>Fortschr Med. 1991 Apr 10;109(11):248-50</Citation><ArticleIdList><ArticleId IdType="pubmed">1855751</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin J Pain. 2004 Jan-Feb;20(1):13-8</Citation><ArticleIdList><ArticleId IdType="pubmed">14668651</ArticleId></ArticleIdList></Reference><Reference><Citation>Rheum Dis Clin North Am. 2008 May;34(2):455-67</Citation><ArticleIdList><ArticleId IdType="pubmed">18638686</ArticleId></ArticleIdList></Reference><Reference><Citation>Z Naturforsch C J Biosci. 1998 Mar-Apr;53(3-4):233-40</Citation><ArticleIdList><ArticleId IdType="pubmed">9687162</ArticleId></ArticleIdList></Reference><Reference><Citation>Z Naturforsch C J Biosci. 1998 Mar-Apr;53(3-4):241-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9687163</ArticleId></ArticleIdList></Reference><Reference><Citation>Drugs Aging. 2017 Apr;34(4):255-264</Citation><ArticleIdList><ArticleId IdType="pubmed">28224284</ArticleId></ArticleIdList></Reference><Reference><Citation>Forsch Komplementmed. 2011;18(5):249-56</Citation><ArticleIdList><ArticleId IdType="pubmed">22105037</ArticleId></ArticleIdList></Reference><Reference><Citation>Arzneimittelforschung. 1995 Feb;45(2):174-6</Citation><ArticleIdList><ArticleId IdType="pubmed">7710443</ArticleId></ArticleIdList></Reference><Reference><Citation>Wien Med Wochenschr. 2007;157(13-14):343-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17704984</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytomedicine. 2017 Oct 15;34:202-211</Citation><ArticleIdList><ArticleId IdType="pubmed">28899503</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Pologne</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Darmstadt</li></settlement></list><tree><country name="Pologne"><noRegion><name sortKey="Gundermann, Karl Josef" sort="Gundermann, Karl Josef" uniqKey="Gundermann K" first="Karl-Josef" last="Gundermann">Karl-Josef Gundermann</name></noRegion></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Muller, Jurgen" sort="Muller, Jurgen" uniqKey="Muller J" first="Jürgen" last="Müller">Jürgen Müller</name></region><name sortKey="Kraft, Karin" sort="Kraft, Karin" uniqKey="Kraft K" first="Karin" last="Kraft">Karin Kraft</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PoplarV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000136 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000136 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PoplarV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32733586
|texte= STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32733586" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |